HUTCHMED to Present Data at Upcoming AACR Annual Meeting 2024

April 5, 2024 by No Comments

HONG KONG and SHANGHAI, China and FLORHAM PARK, N.J., April 05, 2024 — HUTCHMED (China) Limited (“”) (Nasdaq/AIM:HCM; HKEX:13) today announces that new and updated data from several studies of compounds discovered by HUTCHMED will be presented at the upcoming American Association of Cancer Research (“AACR”) Annual Meeting 2024, taking place on April 5-10, 2024 in San Diego, California.

Initial preclinical data will be presented for HMPL-506, a novel, highly potent and differentiated menin-MLL inhibitor for the treatment of certain types of acute leukemia. Compared with five other menin inhibitors in clinical development, HMPL-506 showed the stronger inhibitory potency in MLL-rearranged and NPM1 mutant leukemia cell line models. Furthermore, HMPL-506 in combination with azacytidine, venetoclax or gilteritinib synergistically improved the anti-tumor effect against MLL-rearranged leukemias both in vitro and in vivo. The investigational drug candidate displayed favorable pharmacokinetic profiles, high selectivity and low risk of cardiac toxicity. A Phase I study of HMPL-506 is planned for the second half of 2024.

Initial preclinical data will also be presented for HMPL-A067 (HMA800067), a novel CD38-targeting antibody-drug conjugate (ADC) in which daratumumab was conjugated with cytotoxic payload Monomethyl auristatin E (MMAE) via a novel linker. It demonstrated significant superior anti-tumor activity to daratumumab, including in several B-cell malignancies models with resistance to daratumumab treatment.

Other presentations include preclinical data on the ERK 1/2 inhibitor, HMPL-295; early clinical data on the Syk inhibitor, sovleplenib, in lymphoma patients; additional clinical data from global studies of VEGFR inhibitor, fruquintinib, and MET inhibitor, savolitinib; and several investigator-initiated studies of fruquintinib and VEGFR/CSF-1R/FGFR inhibitor, surufatinib.

Details of the presentations are as follows:

Abstract titlePresenter / Lead authorPresentation detailsSPONSORED STUDIES

HMPL-506, a novel, highly potent and differentiated menin-MLL inhibitor for the treatment of MLL-rearranged and NPM1mutant acute leukemia in preclinical models
Min Cheng, HUTCHMED, Shanghai, ChinaPoster Session (PO.ET07.02 – Pharmacodynamic Biomarkers of Drug Response)
Monday, April 8, 2024
HMPL-A067 (HMA800067), a novel CD38-targeting antibody-drug conjugate (ADC), demonstrated superior anti-tumor activity to daratumumab in preclinical B-cell malignancies models
Yan Xu, HUTCHMED, Shanghai, ChinaPoster Session (PO.ET01.02 – Antibody-Drug Conjugates and Bispectific Antibodies)
Monday, April 8, 2024
Preclinical characterization of HMPL-295, a potent and selective ERK1/2 inhibitor
Jia Hu, HUTCHMED, Shanghai, ChinaPoster Session (PO.MCB03.01 – Cell Signaling Components as Therapeutic Targets)
Monday, April 8, 2024
Targeting YAP1/TEAD signaling re-sensitizes MAPK/ERK pathway inhibitors in KRAS-driven cancer cells
Xianwen Yang, HUTCHMED, Shanghai, ChinaPoster Session (PO.ET03.04 – Drug Resistance 2: Ras GTPase)
Monday, April 8, 2024
Safety and Efficacy of Sovleplenib (HMPL-523), a Syk Inhibitor, in Patients with Relapsed or Refractory Lymphoma
Paolo Strati, The University of Texas MD Anderson Cancer Center, USAPoster Session (PO.CT01.03 – Phase 0 and Phase I Clinical Trials)
Monday, April 8, 2024
Early carcinoembryonic antigen (CEA) dynamics to predict the efficacy of fruquintinib (F) + best supportive care (BSC) in patients with metastatic colorectal cancer (mCRC) enrolled in FRESCO-2
Stefano Lonardi, Veneto Institute of Oncology IOV-IRCCS Padua, ItalyPoster Session (PO.CL01.10 – Predictive Biomarkers 5)
Tuesday, April 9, 2024
Savolitinib (savo) + osimertinib (osi) vs savo + placebo (PBO) in patients (pts) with EGFR-mutated (EGFRm), MET-amplified advanced NSCLC with progression on osi
James Chih-Hsin Yang, National Taiwan University Hospital and National Taiwan University Cancer Centre, Taipei, TaiwanPoster Session (PO.CL01.10 – Predictive Biomarkers 5)
Tuesday, April 9, 2024